Degradation, Bone Regeneration and Tissue Response of an Innovative Volume Stable Magnesium-Supported GBR/GTR Barrier Membrane

• DOI: 10.3390/ijms21093098
• Publication Date: 2020-04-28T14:30:58Z
• Authors: Mike Barbeck; Lennart Kühnel; Frank Witte; Jens Pissarek; Clarissa Precht; Xin Xiong; Rumen Krastev; Nils Wegner; Frank Walther; Ole Jung
• Keywords: Barrier membrane

Introduction: Bioresorbable collagenous barrier membranes are used to prevent premature soft tissue ingrowth and allow bone regeneration. For volume stable indications, only non-absorbable synthetic materials available. This study investigates a new bioresorbable hydrofluoric acid (HF)-treated magnesium (Mg) mesh in native collagen membrane for situations. Materials Methods: HF-treated untreated Mg were compared direct indirect cytocompatibility assays. In vivo, 18 New Zealand White Rabbits received each four 8 mm calvarial defects divided into groups: (a) mesh/collagen membrane, (b) (c) (d) sham operation. After 6, 12 weeks, degradation regeneration was measured using radiological histological methods. Results: vitro, showed higher cytocompatibility. Histopathologically, HF-Mg prevented gas cavities degraded by mononuclear cells via phagocytosis up weeks. Untreated partially significant more fibrous reaction. Bone not significantly different between all groups. Discussion Conclusions: meshes embedded represent biocompatible alternative the materials. shows less corrosion is phagocytosis. However, application of did result