Circulating Long Noncoding RNA LNC-EPHA6 Associates with Acute Rejection after Kidney Transplantation

• DOI: 10.3390/ijms21165616
• Publication Date: 2020-08-05T19:13:18Z
• Authors: Koen E. Groeneweg; Jacques M.G.J. Duijs; Barend W. Florijn; Cees van Kooten; Johan W. de Fijter; Anton Jan van Zon...; Marlies E.J. Rein...; Roel Bijkerk
• Keywords: MALAT1; Thrombomodulin

Acute rejection (AR) of a kidney graft in renal transplant recipients is associated with microvascular injury dysfunction and, ultimately, failure. Circulating long noncoding RNAs (lncRNAs) may be suitable markers for vascular the context AR. Here, we first investigated effect AR after transplantation on local integrity and demonstrated that capillary density markedly decreased biopsies compared to pre-transplant biopsies. Subsequently, assessed circulating levels four lncRNAs (LNC-RPS24, LNC-EPHA6, MALAT1, LIPCAR), were previously associate cohort stable function (n = 32) 15). The latter followed longitudinally six 12 months rejection. We found higher LNC-EPHA6 during rejection, (p 0.017), normalized one year In addition, LNC-RPS24, LIPCAR correlated significantly marker soluble thrombomodulin. conclude are which emphasizes potential role as biomarker