Semi-Quantitative [18F]FDG-PET/CT ROC-Analysis-Based Cut-Offs for Aortitis Definition in Giant Cell Arteritis

• DOI: 10.3390/ijms232415528
• Publication Date: 2022-12-08T07:17:57Z
• Authors: Olivier Espitia; Jérémy Schanus; Christian Agard; Françoise Kraeber...; Alexis F. Guédon; Antoine Bénichou; Jean-Michel Serfaty; Sandrine Coudol; Matilde Karakachoff; Bastien Jamet
• Keywords: Aortitis; Atheroma; Arteritis

[18F]fluorodeoxyglucose-positron emission tomography/computed tomography ([18F]FDG-PET/CT) is used to diagnose large vessel vasculitis in giant cell arteritis (GCA). We aimed define a semi-quantitative threshold for identifying GCA aortitis from aortic atheroma or the control. Contrast enhanced computed (CECT) was as reference imaging evaluation and aortitis, control aortas. [18F]FDG-PET/CT performed on 35 patients two different groups (aortic (n = 70) normal 35)). Aortic features were compared between three groups. without CECT excluded. Of patients, 19 (54.3%) not glucocorticoids (GC) prior [18F]FDG-PET/CT. The SUVmax, TBRblood TBRliver values significantly higher group than (p < 0.001). Receiver operating characteristic curve analyses brought light quantitative cut-off allowing diagnosis with optimal sensitivity specificity versus each PET-based feature analyzed. Considering overall aorta, SUVmax of 3.25 1.75 had 83% 75%, respectively, 81% 81%, area under ROC (AUC) 0.86 0.83, detection cases GC. A 3.45 1.97 90% 93%, 89% 89%, an AUC 0.89 0.96, GC-free cases. Discriminative thresholds established using imaging.