About a Possible Impact of Endodontic Infections by Fusobacterium nucleatum or Porphyromonas gingivalis on Oral Carcinogenesis: A Literature Overview

• DOI: 10.3390/ijms25105083
• Publication Date: 2024-05-07T13:03:38Z
• Authors: Luca Ciani; Antonio Libonati; Maria Dri; Silvia Pomella; Vincenzo Campanella; Giovanni Barillari
• Keywords: endodontic infections; odontogenic tumors; Fusobacterium nucleatum; Carcinogenesis; oral premalignant diseases; 610; Review; Settore MED/05; oral squamous cell carcinoma; endodontic neoplasms; Fusobacterium Infections; Bacteroidaceae Infections; Carcinoma, Squamous Cell; Humans; Animals; Cytokines; Mouth Neoplasms; Settore MEDS-02/B - Patologia clinica; Periodontitis; Porphyromonas gingivalis

Periodontitis is linked to the onset and progression of oral squamous cell carcinoma (OSCC), an epidemiologically frequent and clinically aggressive malignancy. In this context, Fusobacterium (F.) nucleatum and Porphyromonas (P.) gingivalis, two bacteria that cause periodontitis, are found in OSCC tissues as well as in oral premalignant lesions, where they exert pro-tumorigenic activities. Since the two bacteria are present also in endodontic diseases, playing a role in their pathogenesis, here we analyze the literature searching for information on the impact that endodontic infection by P. gingivalis or F. nucleatum could have on cellular and molecular events involved in oral carcinogenesis. Results from the reviewed papers indicate that infection by P. gingivalis and/or F. nucleatum triggers the production of inflammatory cytokines and growth factors in dental pulp cells or periodontal cells, affecting the survival, proliferation, invasion, and differentiation of OSCC cells. In addition, the two bacteria and the cytokines they induce halt the differentiation and stimulate the proliferation and invasion of stem cells populating the dental pulp or the periodontium. Although most of the literature confutes the possibility that bacteria-induced endodontic inflammatory diseases could impact on oral carcinogenesis, the papers we have analyzed and discussed herein recommend further investigations on this topic.