Comparison of In-Hospital Outcomes between Early and Late Catheter-Directed Thrombolysis in Acute Pulmonary Embolism: A Retrospective Observational Study

• DOI: 10.3390/jcm13041093
• Publication Date: 2024-02-15T08:57:29Z
• Authors: Majd Alhuarrat; Kirolos Barssoum; Medhat Chowdhury; Sheetal Mathai; Miriam Helft; Michael Grushko; Prabhjot Singh; Hani Jneid; Afaq Motiwala; Robert Faillace; Seth Sokol
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Article

The purpose of this study is to evaluate whether early initiation catheter-directed thrombolysis (CDT) in patients presenting with acute pulmonary embolism associated improved in-hospital outcomes. A retrospective cohort was extracted from the 2016-2019 National Inpatient Sample database, consisting 21,730 weighted admissions undergoing CDT PE. From time admission, sample divided into (<48 h) and late interventions (>48 h). Outcomes were measured using regression analysis propensity score matching. No significant differences mortality, cardiac arrest, cardiogenic shock, or intracranial hemorrhage (p > 0.05) found between groups. Late had a higher likelihood receiving systemic (3.21 [2.18-4.74], p < 0.01), blood transfusion (1.84 [1.41-2.40], intubation (1.33 [1.05-1.70], = 0.02), discharge disposition care facilities (1.32 [1.14-1.53], 0.01). having kidney injury (1.42 [1.25-1.61], Predictors intervention older age, female sex, non-white ethnicity, non-teaching hospital hospitals bed sizes, weekend admission This represents comprehensive evaluation outcomes interval for initiating CDT, revealing reduced morbidity intervention. Additionally, it identifies predictors delayed initiation. broader ramifications these findings, particularly relation resource utilization health disparities, warrant further exploration.