Evaluation of Acute Pancreatitis Severity and Prognosis Using the Aggregate Systemic Inflammation Index (AISI) as a New Marker: A Comparison with Other Inflammatory Indices
DOI:
10.3390/jcm14103419
Publication Date:
2025-05-14T12:44:58Z
AUTHORS (7)
ABSTRACT
Background/Objectives: Acute pancreatitis (AP) remains a pressing clinical challenge, largely due to its potential lead life-threatening complications and increased mortality. Over the years, numerous tools have been proposed evaluate intensity of AP estimate likely health outcomes. Despite their usefulness, many these assessment models are complex rely on wide array inputs, making them less practical in everyday healthcare settings. In contrast, Aggregate Systemic Inflammation Index (AISI), which is calculated using routine blood count parameters, provides simpler more inclusive approach measuring systemic inflammation. This research focuses examining how effectively AISI can be used gauge disease severity project trajectories individuals affected by pancreatitis. Methods: retrospective study reviewed medical records 412 diagnosed with acute pancreatitis, all whom received care at Internal Medicine Clinic Ankara Bilkent City Hospital between 1 April 2019 September 2024. The investigation encompassed thorough analysis patients' demographic characteristics, lab findings, special attention given inflammatory markers, including revised version, Platelet-to-Lymphocyte Ratio (PLR), Neutrophil-to-Lymphocyte (NLR), Inflammatory Response (SIRI). Comparative analyses groups were performed independent sample t-tests one-way ANOVA, complemented Tukey's post hoc tests where appropriate. Correlations among continuous variables determined through Pearson's analysis, prognostic accuracy both modified form was assessed Receiver Operating Characteristic (ROC) curve methodology. Results: mean age participants 63.47 ± 17.92 while average value as 1183.89 1067.42. Both original versions index showed strong positive correlations several key measures, prolonged hospitalization, Glasgow score 2 or above, BISAP, Ranson scoring, Atlanta classification, APACHE II. also significantly linked presence overall mortality (p < 0.01). Analysis ROC curves demonstrated that an level above 236.626 predicted hospital stays exceeding 10 days, sensitivity 94.40% specificity 91.00%. Moreover, reliably distinguished patients who had zero, high diagnostic accuracy. Conclusions: version demonstrate association course Thanks simplicity, low cost, broad usability settings, indices hold considerable promise dependable for assessing outcomes this increasingly prevalent disease.
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