Altered GH-IGF-1 Axis in Severe Obese Subjects is Reversed after Bariatric Surgery-Induced Weight Loss and Related with Low-Grade Chronic Inflammation

• DOI: 10.3390/jcm9082614
• Publication Date: 2020-08-12T13:14:49Z
• Authors: Paula Juiz-Valiña; Lara Pena-Bello; Maria Cordido; Elena Outeiriño-B...; Sonia Pértega; Barbara Varela-Ro...; Maria Jesus Garci...; Enrique Mena; Susana Sangiao-Al...; Fernando Cordido
• Keywords: Bariatric surgery; 0301 basic medicine; 2. Zero hunger; obesity; Somatotropic axis; bariatric surgery; Article; GH; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Endocrine disorders; IGF-1; somatotropic axis; endocrine disorders; Obesity; 10. No inequality

Endocrine disorders are common in obesity, including altered somatotropic axis. Obesity is characterized by reduced growth hormone (GH) secretion, although the insulin-like factor-1 (IGF-1) values controversial. The aim of this study was to evaluate effect weight loss after bariatric surgery GH–IGF-1 axis extreme order investigate IGF-1 and mechanism responsible for alteration obesity. We performed an interventional trial morbidly obese patients who underwent surgery. included 116 (97 women) 41 controls (30 women). primary endpoint circulating GH values. Circulating were lower than controls. increased significantly over time Post-surgery changes negatively correlated with C-reactive protein (CRP) free T4 After adjusting preoperative body mass index (BMI), CRP a multivariate model, only independently associated follow-up. In summary, severe obesity functional hyposomatotropism at central peripheral level that progressively reversible loss, low-grade chronic inflammation could be principal mediator.