Sinonasal Hyalinizing Adenoid Cystic Carcinoma Is Molecularly Different from Its Salivary and Breast Counterparts

• DOI: 10.3390/jmp4020010
• Publication Date: 2023-05-16T06:37:51Z
• Authors: Ebtissam Alerraqi; Essam Mandour; Mariz Faltas
• Keywords: Adenoid Cystic Carcinoma; Cribriform

Adenoid cystic carcinoma (AdCC) is known to behave differently based on its location, histologic features, and molecular profile. Despite this understanding, efforts use these findings develop personalized treatments have not yet been successful. The purpose of retrospective study examine the characteristics AdCC with various features in three different locations. A reference group 20 classic cribriform cases from parotid gland was included, along 10 salivary AdCCs (Group 1), sinonasal hyalinization 2), solid mammary basaloid 3). Tissue samples were processed tested using techniques, Wilcoxon signed-rank test used compare groups. Molecular data obtained for both common rare sinonasal, salivary, AdCCs, revealing differences depending tumor’s location. profile experimental varied site, MYB gene rearrangements being all cases. We report first MYB::KMT2C/D fusions a subset but adenoid features. conclude that co-occurring genetic alterations may vary among sites implications prognosis treatment plan AdCC. More research needed fully understand mechanisms KMT2C KMT2D mutations development progression head neck cancer, including their interactions NOTCH pathway.