Tributyl(1-((dimethylamino)(dimethyliminio)methyl)-1,4-dihydropyridin-4-yl)phosphonium Ditrifluoromethanesulfonate

• DOI: 10.3390/m1710
• Publication Date: 2023-08-09T14:30:48Z
• Authors: Yiwei Gong; Jas S. Ward; Kari Rissanen; Florian F. Mulks
• Keywords: Phosphonium; Surface Modification; Tributylphosphine; Hydrogen fluoride

Site-selective functionalization of pyridines is a crucial tool for the synthesis diverse pharmaceuticals and materials. We introduced diiminium pyridine adducts as highly convenient potent Lewis acids. report that tributylphosphine selectively adds to 4-position in tetramethyldiiminium ditrifluoromethanesulfonate, resulting formation title compound. This finding represents an advancement towards utilization units organic reagents or catalysts functionalization. also employ computational models determine fluoride hydride ion affinities, Fukui function f+(r), molecular electrostatic potential, pKa values, providing valuable insights future investigations this area.