Synthesis of Dimethyl (Z)-((3-oxoindolin-2-ylidene) (aryl)methyl)phosphonates Through Tandem Cadogan and Arbuzov Reactions

• DOI: 10.3390/m2002
• Publication Date: 2025-05-05T08:31:36Z
• Authors: Nicolai A. Aksenov; Dmitrii A. Aksenov; Daniil D. Ganusenko; Alexander E. Kurl...; Alexander P. Barb...; Polina S. Karaseva; Alexander V. Aksenov

A novel method employing a tandem Cadogan and Arbuzov reaction sequence has been developed, providing access to a series of previously unreported dimethyl (Z)-((3-oxoindolin-2-ylidene)(aryl)methyl)phosphonates. Restricted rotation of the aryl substituent, particularly in the presence of ortho substituents, gives axial chirality to these compounds.