Antihypertensive Effect of Long-Term Oral Administration of Jellyfish (Rhopilema esculentum) Collagen Peptides on Renovascular Hypertension

• DOI: 10.3390/md10020417
• Publication Date: 2012-02-15T17:03:12Z
• Authors: Yongliang Zhuang; Liping Sun; Yufeng Zhang; Gaoxiang Liu
• Keywords: Male; 0301 basic medicine; kidney; Time Factors; Scyphozoa; QH301-705.5; Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; angiotensin II; Kidney; 03 medical and health sciences; Heart Rate; Animals; Biology (General); Rats, Wistar; Antihypertensive Agents; Dose-Response Relationship, Drug; Communication; Angiotensin II; jellyfish; blood pressure; Peptide Fragments; Rats; 3. Good health; Disease Models, Animal; Hypertension, Renovascular; Collagen; collagen peptide

Antihypertensive effect of long-term oral administration of jellyfish (Rhopilema esculentum) collagen peptides (JCP) on renovascular hypertension rats (RVHs) was evaluated. The systolic blood pressure and diastolic blood pressure of the RVHs were significantly reduced with administration of JCP (p < 0.05), compared with model control group. However, the arterial blood pressure of normal rats showed no significant changes during long-term oral treatment with high dose JCP (p > 0.05). Furthermore, effect of JCP on angiotensin II (Ang II) concentration of plasma had no significance (p > 0.05), but JCP significantly inhibited the Ang II concentration in RVHs’ kidney (p < 0.05). The kidney should be the target site of JCP.