New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp.

• DOI: 10.3390/md10092023
• Publication Date: 2012-09-18T15:13:20Z
• Authors: Bin Yang; Xuefeng Zhou; Hui Huang; Xian-Wen Yang; Juan Liu; Xiuping Lin; Xiubao Li; Yan Peng; Yonghong Liu
• Keywords: Magnetic Resonance Spectroscopy; NF-kappa B; Anthozoa; <em>Sinularia</em> sp.; cembrane diterpenoids; NF-κB inhibitor; 01 natural sciences; Article; Cell Line; 0104 chemical sciences; HEK293 Cells; Animals; Humans; Diterpenes

Five new cembrane diterpenoids, named sinuflexibilins A–E (1–5), along with nine other known diterpenoids (6–14), have been isolated from the organic extract of a Hainan soft coral Sinularia sp. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison of their spectral data with those of related metabolites. Compound 13, flexibilide, exhibited significant inhibitory activity of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay.