Bioactive Lipids of Marine Microalga Chlorococcum sp. SABC 012504 with Anti-Inflammatory and Anti-Thrombotic Activities

• DOI: 10.3390/md19010028
• Publication Date: 2021-01-11T02:21:45Z
• Authors: Katie Shiels; Alexandros Tsoupras; Ronan Lordan; Constantina Nasop...; Ioannis Zabetakis; Patrick Murray; Sushanta Kumar Saha
• Keywords: Phosphatidylethanolamine; Nutraceutical

Microalgae are at the start of food chain, and many known producers a significant amount lipids with essential fatty acids. However, bioactivity microalgal for anti-inflammatory antithrombotic activities have rarely been investigated. Therefore, sustainable source above bioactive lipids, present study was undertaken. The total microalga Chlorococcum sp., isolated from Irish coast, were fractionated into neutral-, glyco-, phospho-lipids, tested in vitro their activities. All lipid fractions showed strong anti-platelet-activating factor (PAF) antithrombin human platelets (half maximal inhibitory concentration (IC50) values ranging ~25–200 μg lipid) highest glyco- phospho-lipid fractions. structural analysis fraction-2 revealed presence specific sulfoquinovosyl diacylglycerols (SQDG) molecules HexCer-t36:2 (t18:1/18:1 18:2/18:0) cerebrosides phytosphingosine (4-hydrosphinganine) base, while fraction-3 contained phosphatidylcholine (PC) phosphatidylethanolamine (PE) molecules. These novel sp. putative health benefits may indicate that marine microalgae can be alternative production supplements nutraceutical applications. further studies required towards commercial technology pathways development biosafety use microalga.