Impact of Human Milk Oligosaccharides and Probiotics on Gut Microbiome and Mood in Autism: A Case Report

• DOI: 10.3390/microorganisms12081625
• Publication Date: 2024-08-09T11:59:07Z
• Authors: Luana Aldegheri; Feras Kharrat; Andrea Conti; Fabio Monica; Francesca Busa; Giuseppina Campis...; Nunzia Zanotta; Carolina Cason; Manola Comar
• Keywords: 0301 basic medicine; HMOs; 03 medical and health sciences; QH301-705.5; microbiome; next-generation sequencing; autism spectrum disorder; Case Report; Biology (General); cytokines

Recent evidence has highlighted the role of the gut–brain axis in the progression of autism spectrum disorder (ASD), with significant changes in the gut microbiome of individuals with this condition. This report investigates the effects of probiotics and human milk oligosaccharide (HMO) supplements on the gut microbiome, inflammatory cytokine profile, and clinical outcomes in an ASD adolescent with chronic gastrointestinal dysfunction and cognitive impairment. Following treatment, we observed a decrease in proinflammatory cytokines’ concentration alongside Sutterella relative abundance, a bacterium reported to be linked with gastrointestinal diseases. Also, we reported a notable increase in mood stability. The study aims to evaluate the use of gut microbiome-based therapy in selected ASD patients, highlighting its potential to improve related clinical symptoms.