Prevalence of Antimicrobial Resistance in Klebsiella pneumoniae, Enterobacter cloacae, and Escherichia coli Isolates among Stillbirths and Deceased Under-Five Children in Sierra Leone: Data from the Child Health and Mortality Prevention Surveillance Sites from 2019 to 2022

• DOI: 10.3390/microorganisms12081657
• Publication Date: 2024-08-13T10:02:37Z
• Authors: Julius Ojulong; Gebrekrstos N. Gebru; Babatunde Duduyemi; Edwin Gbenda; Mohamed L. Janneh; Jack Sharty; Leonel Monteiro; Dickens Kowuor; Soter Ameh; Ikechukwu U. Ogbuanu
• Keywords: Enterobacter cloacae; Ertapenem

Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloacae are associated with most nosocomial infections worldwide. Although gaps remain in the knowledge of their susceptibility patterns, these antimicrobial stewardship. This study aimed to describe profiles above organisms isolated from postmortem blood stillbirths under-five children enrolled Child Health Mortality Prevention Surveillance (CHAMPS) program Sierra Leone. was a surveillance bacteria isolates cultures taken within 24 h death aged 0–59 months between March 2019 February 2022. followed by identification antibiotic sensitivity testing using Becton Dickinson Phoenix M50 (USA). Descriptive analysis used characterize patterns. Of 367 isolates, K. pneumoniae frequently organism (n = 152; 41.4%), E. coli 40; 10.9%) 35; 9.5%). Using BACTEC™ FX 40 (Franklin Lakes, NJ, USA), were identified bacteriological methods. Extended spectrum beta-lactamase (ESBL) observed 143 (94.1%) 27 (65.5%) isolates. Carbapenem-resistant (CRO) seen 31 (20.4%) 5 (12.5%) A multidrug resistance (MDR) pattern prevalent E.cloacae (33/35; 94.3%), (138/152; 90.8%). Our showed high prevalence among bacterial catchment areas under CHAMPS sites