Prenatal and Peripartum Exposure to Antibiotics and Cesarean Section Delivery Are Associated with Differences in Diversity and Composition of the Infant Meconium Microbiome

• DOI: 10.3390/microorganisms8020179
• Publication Date: 2020-01-27T16:41:57Z
• Authors: Wendy S.W. Wong; Priya Sabu; Varsha Deopujari; Shira Levy; Ankit A. Shah; Nicole Clemency; Marina Provenzano; Reem Saadoon; Akhil Munagala; Robin Baker; Rajiv Baveja; Noel T. Mueller; Maria Gloria Domi...; Kathi Huddleston; John E. Niederhuber; Suchitra K. Hourigan
• Keywords: Section (typography); Prenatal Care

The meconium microbiome may provide insight into intrauterine and peripartum exposures the very earliest intestinal pioneering microbes. Prenatal antibiotics have been associated with later obesity in children, which is thought to be driven by dependent mechanisms. However, there little data regarding associations of prenatal or antibiotic exposure, without cesarean section (CS), features microbiome. In this study, 16S ribosomal RNA gene sequencing was performed on bacterial DNA samples from 105 infants a birth cohort study. After multivariable adjustment, delivery mode (p = 0.044), use 0.005) < 0.001) were beta diversity infant CS (vs. vaginal delivery) also greater alpha (Shannon Simpson, p 0.05). Meconium born had lower relative abundance genus Escherichia 0.001). (both overall analytic sample when restricting vaginally delivered infants) differential several taxa meconium. Bacterial differentially excess weight at 12 months age, however, size limited for comparison. conclusion, along differences composition Whether not these portend risk long-term health outcomes warrants further exploration.