Nasal Microbiota in RSV Bronchiolitis

• DOI: 10.3390/microorganisms8050731
• Publication Date: 2020-05-14T14:27:19Z
• Authors: Serena Schippa; Antonella Frassanito; Massimiliano Mara...; Raffaella Nenna; Laura Petrarca; Bruna Neroni; Giulia Bonfiglio; Francesca Guerrieri; Federica Frasca; Giuseppe Oliveto; Alessandra Pieran...; Fabio Midulla
• Keywords: Clearance; Group A

Respiratory Syncytial Virus (RSV) is the leading cause of bronchiolitis, and severity may be influenced by bacterial ecosystem. Our aim was to analyze nasal microbiota from 48 infants affected bronchiolitis RSV virus 28 with but negative for virus. Results showed a significantly lower biodiversity in RSV-positive group respect RSV-negative group, specific microbial profile associated different that observed significant modifications relative abundance taxa as well RSV-A group. Furthermore, network analyses evidenced, all studied groups, presence two predominant sub-networks characterized peculiar inter- intra-group correlation patterns general loss connectivity among microbes particularly results indicated more severe disease, caused infection, present perturbations both structure relationships. Patients milder course (RSV-B-infected patients who have cleared virus) presented less alterations.