Differences in the On- and Off-Tumor Microbiota between Right- and Left-Sided Colorectal Cancer

• DOI: 10.3390/microorganisms9051108
• Publication Date: 2021-05-20T15:45:57Z
• Authors: Oliver Phipps; Mohammed N. Quraishi; Edward A. Dickson; Helen Steed; Aditi Kumar; Austin G. Acheson; Andrew D. Beggs; Matthew J. Brookes; Hafid Omar Al-Hassi
• Keywords: Ruminococcus

This study aims to determine differences in the on- and off-tumor microbiota between patients with right- left-sided colorectal cancer. Microbiome profiling of tumor tumor-adjacent biopsies from right-sided (n = 17) 7) adenocarcinoma was performed using 16S ribosomal RNA sequencing. Off-tumor alpha beta diversity were significantly different cancer patients. However, no on-tumor observed locations. Comparing showed right colon be enriched species Lachnoclostridium, Selenomonas, Ruminococcus genera. Whereas left is Epsilonbacteraeota phylum, Campylobacteria class, Pasteurellales Campylobacterales orders, contrast, relatively fewer bacterial taxonomy sites, tumors being Methylophilaceae Vadin BE97 families Alloprevotella, Intestinibacter, Romboutsia, 2 Patients had large taxonomic their paired microbiota, while differences. Collectively, this suggests that show distinctive populations; however, presence a colonic leads more consistent