Phaleria macrocarpa Boerl. (Thymelaeaceae) Leaves Increase SR-BI Expression and Reduce Cholesterol Levels in Rats Fed a High Cholesterol Diet

• DOI: 10.3390/molecules20034410
• Publication Date: 2015-03-09T15:47:19Z
• Authors: Yosie Andriani; Tengku Tengku-Muh...; Habsah Mohamad; Jasnizat Saidin; Desy Syamsumir; Guat-Siew Chew; Mohd Abdul Wahid
• Keywords: Transaminase; Thymelaeaceae; Aspartate transaminase

In vitro and in vivo studies of the activity Phaleria macrocarpa Boerl (Thymelaeaceae) leaves against therapeutic target for hypercholesterolemia were done using HDL receptor (SR-BI) hypercholesterolemia-induced Sprague Dawley rats. The study showed that active fraction (CF6) obtained from ethyl acetate extract (EMD) its component 2',6',4-trihydroxy-4'-methoxybenzophenone increased SR-BI expression by 95% 60%, respectively. has proven effect EMD at 0.5 g/kgbw dosage reducing total cholesterol level 224.9% increasing 157% compared to group. toxicity study, serum glutamate oxalate transaminase (SGOT) pyruvate (SGPT) observed be normal levels. liver histology also proved no abnormalities any treatment groups, so it can categorized as non-toxic rat liver. findings taken together show P. are safe suitable an alternative control prevention