In Vitro Anti-Toxoplasma gondii and Antimicrobial Activity of Amides Derived from Cinnamic Acid

• DOI: 10.3390/molecules23040774
• Publication Date: 2018-03-29T09:26:37Z
• Authors: Graziela Silveira; Karoline Campelo; Gleice Lima; Lais Carvalho; Solange Samarão; Olney Vieira-da-M...; Leda Mathias; Carlos Matos; Ivo Vieira; Edesio Melo; Edmilson Maria
• Keywords: Antiparasitic; Cinnamic acid; Broth microdilution

Most cinnamic acids, their esters, amides, aldehydes, and alcohols present several therapeutic actions through anti-inflammatory, antitumor, inhibitory activity against a great variety of microorganisms. In this work, eight amines derived from acid were synthesized tested host cells infected with Toxoplasma gondii the bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis, three strains aureus. Compounds 3 4 showed best result intracellular T. gondii, presenting antiparasitic at low concentrations (0.38 0.77 mM). The antibacterial these compounds was also evaluated by agar microdilution method, amides 2 5 had minimum concentration 250 µg mL−1 two S. aureus (ATCC 25923 bovine strain LSA 88). These synergistic action along antibiotics, demonstrating that have potential as pharmacological agents.