New Derivatives of 5-Substituted Uracils: Potential Agents with a Wide Spectrum of Biological Activity

• DOI: 10.3390/molecules27092866
• Publication Date: 2022-05-01T10:23:08Z
• Authors: Vasily A. Kezin; Elena S. Matyugina; Mikhail S. Novikov; Alexander O. Chizhov; Robert Snoeck; Graciela Andrei; Sergei N. Kochetkov; Anastasia L. Khan...
• Keywords: Broad spectrum

Pyrimidine nucleoside analogues are widely used to treat infections caused by the human immunodeficiency virus (HIV) and DNA viruses from herpes family. It has been shown that 5-substituted uracil derivatives can inhibit HIV-1, family viruses, mycobacteria other pathogens through various mechanisms. Among pyrimidine nucleosides, there not only classical inhibitors of 2′-deoxy-5-iodocytidine 5-bromovinyl-2′-deoxyuridine, but also 1-(benzyl)-5-(phenylamino)uracil, which proved be non-nucleoside HIV-1 EBV. made this modification very promising in connection with emergence new crisis drug resistance when task creating effective antiviral agents types act on targets or exhibit activity mechanisms is urgent. In paper, we present design, synthesis primary screening biological analogues, namely, 5′-norcarbocyclic substituted 5-arylamino- 5-aryloxyuracils, against RNA viruses.