Secondary Sclerosing Cholangitis in Critically Ill Patients Alters the Gut–Liver Axis: A Case Control Study

• DOI: 10.3390/nu12092728
• Publication Date: 2020-09-07T13:18:16Z
• Authors: Andreas Blesl; Christoph Jüngst; Frank Lammert; Günter Fauler; Florian Rainer; Bettina Leber; Nicole Feldbacher; Silvia Stromberger; Renate Wildburger; Walter Spindelböck; Peter Fickert; Angela Horvath; Vanessa Stadlbauer
• Keywords: Primary Sclerosing Cholangitis

Secondary sclerosing cholangitis in critically ill patients (SC-CIP) occurs after long-term intensive care treatment. This study aimed to assess the gut–liver axis SC-CIP. Stool microbiome composition, gut permeability, bacterial translocation and serum bile acid profiles of 18 SC-CIP compared 11 critical illness without liver disease (CIP controls), 21 with cirrhosis healthy controls were studied. 16S rDNA was isolated from stool sequenced using Illumina technique. Diamine oxidase, zonulin, soluble CD14 (sCD14) lipopolysaccharide binding protein measured calprotectin stool. Serum acids analyzed by high-performance liquid chromatography-mass spectrometry (HPLC-MS). Reduced alpha diversity altered beta seen SC-CIP, CIP controls. showed a shift towards pathogenic taxa an oralization. cirrhotic presented impaired biomarkers increased cirrhosis. Total elevated profile In conclusions, observed alterations cannot solely be attributed disease, but may also secondary