A Prospective, Observational Study of the Effect of a High-Calorie, High-Protein Oral Nutritional Supplement with HMB in an Old and Malnourished or at-Risk-of-Malnutrition Population with Hip Fractures: A FracNut Study

• DOI: 10.3390/nu16081223
• Publication Date: 2024-04-19T14:53:17Z
• Authors: Teresa Pareja Sierra; Flavia Hünicken T...; María Pablos Hern...; Rosario López Vel...; Raquel Ortés Gómez; María Cervera Díaz; Ana Hormigo Sánchez; Beatriz Perdomo R...; Jesús Mora Fernández; Sonia Jiménez Mola; María Rodriguez P...; Patricia Condorhu...; Carlos Sanchez Juan; Juan Ramos Clemente; Silvia Veses Martín; Ingrid Rodríguez ...; Magali González-C...; María Camprubí Ro...; Andrea Martín Agu...; Pilar Saez Lopez
• Keywords: Male; Aged, 80 and over; Hip Fractures; ONS-beta-hydroxy-beta-methylbutyrate; Malnutrition; Nutritional Status; Administration, Oral; malnutrition; Article; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; hip fracture; Dietary Supplements; Valerates; Diet, High-Protein; Humans; Female; Prospective Studies; Dietary Proteins; Energy Intake; Aged

Hip fractures are prevalent among older people, often leading to reduced mobility, muscle loss, and bone density decline. Malnutrition exacerbates the prognosis post surgery. This study aimed evaluate impact of a 12-week regimen high-calorie, high-protein oral supplement with β-hydroxy-β-methylbutyrate (HC-HP-HMB-ONS) on nutritional status, daily activities, compliance in malnourished or at-risk patients hip receiving standard care. A total 270 subjects ≥75 years age, residing at home nursing homes, risk malnutrition, fracture surgery, received HC-HP-HMB-ONS for 12 weeks. Various scales questionnaires assessed outcomes. During weeks follow-up, 82.8% consumed ≥75% HC-HP-HMB-ONS. By week 12, 62.4% gained maintained weight (+0.3 kg), 29.2% achieved normal status (mean MNA score +2.8), 46.8% improved status. Biochemical parameters significantly. Subjects reported good tolerability 8.5/10), 87.1% healthcare providers concurring. The administration markedly enhanced biochemical hip-fracture patients, high tolerability. Both professionals expressed satisfaction