Incorporating Immune Cells into Organoid Models: Essential for Studying Human Disease

• DOI: 10.3390/organoids2030011
• Publication Date: 2023-08-14T16:35:25Z
• Authors: Ania Bogoslowski; Meilin An; Josef M. Penninger
• Keywords: Organoid; Human disease

Organoid-based research has made significant discoveries and contributions to our understanding of human organ function in both health disease. To continue making progress, it is crucial acknowledge the role immune system all organs. Various cells, such as macrophages, T neutrophils, are resident almost tissues play essential roles homeostasis, function, Using diverse methods, researchers have begun integrating cells into organoid models, leading more physiologically relevant models that better represent various aspects These methods range from cell injection co-culture tissue expansion with existing cells. Immune can be sourced mature patients or generated stem immature The successful incorporation organoids will enhance provide a accurate approximation