Organoid Models of Lymphoid Tissues

• DOI: 10.3390/organoids4020007
• Publication Date: 2025-04-10T12:46:20Z
• Authors: Ania Bogoslowski; Joice Ren; Clément Quintard; Josef M. Penninger
• Keywords: Organoid

Lymphoid organs are critical for organizing the development of immune system, generating tolerance, and orchestrating adaptive response to foreign antigens. Defects in their structure function can lead immunodeficiency, hypersensitivity, cancer, or autoimmune diseases. To better understand these diseases assess potential therapies, complex models that recapitulate anatomy physiology tissues required. Organoid possess a number advantages, including 3D microarchitecture, scalability, personalization, which make them ideal modelling lymphoid related pathologies. Organoids have been developed both primary secondary tissues; however, several limitations, immature phenotypes incomplete stromal cell populations. Furthermore, organoids often heterogeneous function. Several organs, such as spleen, do not yet robust organoid models, offering opportunities breakthroughs field. Overall, will pave way rapid testing novel organ modelling, personalized medicine. This review summarizes current advances organ—bone marrow thymus—as well lymph node spleen.