Cervical HPV Infections, Sexually Transmitted Bacterial Pathogens and Cytology Findings—A Molecular Epidemiology Study

• DOI: 10.3390/pathogens12111347
• Publication Date: 2023-11-14T14:12:39Z
• Authors: George Valasoulis; Abraham Pouliakis; Georgios Michail; Ioulia Magaliou; Christos Parthenis; Niki Margari; Christine Kottaridi; Aris Spathis; Danai Leventakou; Argyro-Ioanna Ier...; Georgios Androuts...; Periklis Panagopo...; Alexandros Daponte; Sotirios Tsiodras; Ioannis G. Panayi...
• Keywords: Mycoplasma genitalium; Ureaplasma; Mycoplasma hominis; Liquid-based cytology

Prevalent cervical HPV infection and high-risk persistence consequences have been extensively investigated in the literature; nevertheless, any causative interrelations of other sexually transmitted bacterial infections (STIs) with not yet fully elucidated. This study aimed to investigate possible association STIs cytology aberrations genotyping results a representative sample predominantly young Greek women. Liquid-based molecular detection for as well extended were simultaneously assessed samples from 2256 individuals visiting several urban outpatient Gynecology Departments well-woman visits or screening throughout 20-month period. All specimens centrally processed validated assays. The mean age studied women was 37.0 ± 11.7 years; 722 (33.30%) tested positive STI (mean 34.23 10.87 years). A higher (38.34 11.83 years (p < 0.05)) associated negative testing. Chlamydia trachomatis detected 59 (8.2%), Mycoplasma hominis 156 (21.6%), genitalium 14 (1.9%), Ureaplasma spp. 555 (76.9%); two pathogens identified 73 (10.1%). Cervical 357 out 1385 valid typing result (25.8%). HPV-positive 32.0 8.4 testing HPV-negative slightly older (N = 1028): 34.4 9.2 0.05). Among 1371 both detection, an more likely harbor (OR: 2.69, 95% CI 2.10-3.46, p Interestingly, positivity illustrated significant heterogeneity between NILM LSIL cases, 28.88% 46.33% cases harboring STI, respectively In brief, population high prevalence STIs, especially spp., documented pathogen infection, abnormal cytology; these findings merit further investigation.