A Comparison of RML Prion Inactivation Efficiency by Heterogeneous and Homogeneous Photocatalysis

• DOI: 10.3390/pathogens13050420
• Publication Date: 2024-05-16T15:26:17Z
• Authors: Ioannis Paspaltsis; Eirini Kanata; Sotirios Sotiriadis; Susana Silva Correia; Matthias Schmitz; Inga Zerr; Dimitra Dafou; Konstantinos Xant...; Theodoros Sklaviadis
• Keywords: TiO2 photocatalysis; TiO₂ photocatalysis; RML prion; homogeneous photocatalysis; R; Medicine; ddc:610; prion decontamination; prion inactivation; Article; heterogeneous photocatalysis; photo-Fenton reagent

Prions are proteinaceous pathogens responsible for a variety of devastating diseases in mammals, including scrapie sheep and goats, chronic wasting disease cervids, Creutzfeldt–Jakob (CJD) humans. They characterized by their exceptional persistence to common inactivation procedures. This applies all possible sources prion contamination as prions may be present the tissues biological fluids infected individuals. Hence, efficient procedures still being sought minimize risk intra- or inter-species transmission. In past, photocatalytic treatment has been proven capable efficiently oxidizing inactivating prions. study, efficacy homogeneous photo-Fenton-based photocatalysis well heterogeneous with TiO2 reducing RML mouse infectivity was evaluated. Prion assessed means bioassay, results were confirmed vitro experiments. While reduced after photo-Fenton reagent, same strain completely eliminated infectivity.