Naturally Acquired Humoral Immunity against Malaria Parasites in Non-Human Primates from the Brazilian Amazon, Cerrado and Atlantic Forest

• DOI: 10.3390/pathogens9070525
• Publication Date: 2020-06-29T15:17:17Z
• Authors: Eliana Ferreira M...; Carmen Fernandez-...; Maisa da Silva Ar...; Mariluce Rezende ...; Luiz Shozo Ozaki; Ana Maria Ribeiro...; Marina Galvão Bueno; Jose Luiz Catao-Dias; Carolina Romeiro ...; Bruno da Silva Ma...; Mayra Gomes dos S...; Stéfanie Vanessa ...; Marcia Moreira Ho...; Julio Cesar de Souza; Karin Kirchgatter
• Keywords: Plasmodium (life cycle); Plasmodium malariae

Non-human primates (NHPs) have been shown to be infected by parasites of the genus Plasmodium, etiological agent malaria in humans, creating potential risks zoonotic transmission. Plasmodium brasilianum, a parasite species similar P. malariae described NHPs from Central and South America, including Brazil. The merozoite surface protein 1 (MSP1), besides being vaccine candidate, is highly immunogenic. Due such properties, we tested this for diagnosis infection. We used recombinant proteins MSP1, as well falciparum vivax, detection antibodies anti-MSP1 these species, sera collected different regions About 40% NHP were confirmed reactive one or more species. A relatively higher number was found animals Atlantic Forest than those Amazon region, possibly reflecting former intense circulation among due their proximity humans at populational density. presence positive surveyed areas, therefore reservoirs, needs considered any surveillance program.