Improvement of the Thermal Stability and Aqueous Solubility of Three Matrine Salts Assembled by the Similar Structure Salt Formers

• DOI: 10.3390/ph17010094
• Publication Date: 2024-01-10T14:39:57Z
• Authors: Yeyang Wang; Baoxi Zhang; Wenwen Wang; Penghui Yuan; Kun Hu; Li Zhang; Dezhi Yang; Yang Lu; Guanhua Du
• Keywords: Thermal Stability; Thermogravimetry

Matrine (MAT), a natural Chinese herbal medicine, has unique advantage in the treatment of various chronic diseases. However, its low melting point, bioavailability, and high dosage restrict subsequent development into new drugs. In this study, three kinds MAT salts, namely, MAT-2,5-dihydroxybenzoic acid (MAT-25DHB), MAT-2,6-dihydroxybenzoic (MAT-26DHB), MAT-salicylic acid-hydrate (MAT-SAL-H