Characterization of Hydrophilic Polymers as a Syringe Extrusion 3D Printing Material for Orodispersible Film

• DOI: 10.3390/polym13203454
• Publication Date: 2021-10-11T01:37:29Z
• Authors: Pattaraporn Panraksa; Sheng Qi; Suruk Udomsom; Pratchaya Tipduangta; Pornchai Rachtanapun; Kittisak Jantanas...; Pensak Jantrawut
• Keywords: 0404 agricultural biotechnology; disintegration; orodispersible film; 600; syringe extrusion 3D printing; hydrophilic polymer; 04 agricultural and veterinary sciences; 540; 0405 other agricultural sciences; Article; 3. Good health

The application of hydrophilic polymers in designing and three-dimensional (3D) printing pharmaceutical products various dosage forms has recently been paid much attention. Use syringe extrusion 3D technology the fabrication orodispersible films (ODFs) might hold great potential rapid drug delivery, personalized medicine, manufacturing time savings. In this study, feasibility 3D-printed ODFs through a technique using five different (e.g., hydroxypropyl methylcellulose E15, E50, high methoxyl pectin, sodium carboxymethylcellulose, hydroxyethylcellulose) as film-forming materials investigated. Rheology properties printability gels physicochemical mechanical were evaluated. Amongst investigated polymers, carboxymethylcellulose at concentration 5% w/v (SCMC-5) showed promising results with good resolution accurate dimensions ODFs. addition, SCMC-5 exhibited fastest disintegration within 3 s due to wettability, roughness porosity on surface. However, study that printed rigid brittle, thus requiring special packaging prevent them from any damage before practical use.