Formulation Development, Characterization and Antifungal Evaluation of Chitosan NPs for Topical Delivery of Voriconazole In Vitro and Ex Vivo

• DOI: 10.3390/polym14010135
• Publication Date: 2021-12-31T04:29:07Z
• Authors: Muhammad Khurshid...; Abul Kalam Azad; Asif Nawaz; Shafi Ullah; Muhammad Shahid L...; Habibur Rahman; Khalaf F. Alsharif; Khalid J. Alzahrani; Attalla F. El-Kott; Ashraf Albrakati; Mohamed M. Abdel-...
• Keywords: Ex vivo

This study aims to develop chitosan-based voriconazole nanoparticles (NPs) using spray-drying technique. The effect of surfactants and polymers on the physicochemical properties, in vitro release, permeation NPs was investigated. prepared containing various (e.g., Tween 20 (T20), 80 (T80), sodium lauryl sulfate (SLS), propylene glycol (PG), Polyethylene glycol-4000 (PEG-4000)) were physiochemically evaluated for size, zeta potential, drug content, percent entrapment efficiency, across rats' skin. A Franz diffusion cell used evaluating release profile. voriconazole-loaded investigated antifungal activity against Candida albicans (C. albicans). nano range (i.e., 160–500 nm) positively charged. Images taken by a scanning electron microscope showed that all spherical smooth. content ranged from 75% 90%. Nanoparticle formulations exhibited good profile transport rat's skin slow control manner. SLS, T80, PG best penetration retention In addition, formulation potential C. albicans. It concluded development chitosan has great topical delivery fungal infection.