Lornoxicam-Loaded Chitosan-Decorated Nanoemulsion: Preparation and In Vitro Evaluation for Enhanced Transdermal Delivery

• DOI: 10.3390/polym14091922
• Publication Date: 2022-05-10T04:30:28Z
• Authors: Rahman Khan; Shefaat Shah; Sheikh Rashid; Faiza Naseem; Kifayat Shah; Arshad Farid; Khalid Hakeem; Majid Kamli; Eman Althubaiti; Soha Alamoudi
• Keywords: Lornoxicam; Excipient

Nanoemulsions are promising drug delivery systems for the administration of poorly soluble drugs like lornoxicam (LRX) by oral or parenteral routes. Such formulations work perfectly transdermal lornoxicam-type drugs. It has also been established that formulating such a system is highly dependent on presence, type, and concentration excipients taking part in formulation. The inherent characteristics nanoemulsion (NE), i.e., smaller globule size excipient nature, facilitate drug's passage through skin. current study was aimed at development an NE-based formulation LRX to improve solubility vitro as well enhance skin permeation promote therapeutic outcome appropriate time. Spontaneous self-emulsification technique utilized develop optimized LRX-encapsulated formulations. ATR-FTIR spectra pure various did not show any interaction between showing compatibility. Globule stable ranged 63-168 nm. These were characterized viscosity, surface tension, pH, encapsulation efficiency, release, studies. Chitosan-decorated NE showed about 58.82% cumulative anomalous non-Fickian diffusion mechanism release. Drug studies exhibited results. An appreciable entrapment efficiency LRX-6, 71.91 ± 3.17% C-LRX, 65.25 4.89%. Permeability parameters enhancement ratio (Er), permeability constant (Kp), steady state flux (Jss) higher values good results based type. selected type "LRX-6" significantly different compared other (LRX-4, 5, 7). property LRX-6 similar chitosan-based found have better than This clearly LRX-containing can be formulated form system. terms physicochemical characteristics, improved solubility, high potential.