Deciphering the Effect of Hyaluronic Acid/Collagen Hydrogel for Pain Relief and Tissue Hydration in a Rat Model of Intervertebral Disc Degeneration

• DOI: 10.3390/polym16182574
• Publication Date: 2024-09-12T06:30:23Z
• Authors: Rusydi Mohd Razak; Nur Arina Amira H...; Mohammad Ali Zuhd...; Najwa Syakirah Mo...; Raed H. Ogaili; Ahmad Hafiz Kamar...; Muhammad Fakhrull...; Nur Aqilah Kamaru...; Aminatul Saadiah ...; Sabarul Afian Mok...; Isma Liza Mohd Isa
• Keywords: Intervertebral Disc; Degeneration (medical)

Intervertebral disc (IVD) degeneration is one of the primary causes low back pain, causing disability; hence, there no regenerative nature current treatments. Hyaluronic acid (HA) was reported to facilitate tissue repair and alleviate pain. Herein, we determined therapeutic effect HA type II collagen (COLII) hydrogel for targeting pain in IVD degeneration. We implanted HA/COLII following surgically induced injury at coccygeal levels rat tail model assessed efficacy reducing behaviour by using von Frey assessment, protein expression growth-associated (GAP) 43 sensory nerve innervation, hydration magnetic resonance imaging (MRI). observed anti-nociceptive alleviating mechanical allodynia rats. There an inhibition hyperinnervation indicated GAP43 treatment group. revealed increase T1ρ mapping MRI, indicating that restored vivo. Our findings suggest alleviates behaviour, inhibits promotes repair, implying it a potential candidate degenerative disc-associated