Examining the Impact of the 2019 Novel Coronavirus and Pandemic-Related Hardship on Adverse Pregnancy and Infant Outcomes: Design and Launch of the HOPE COVID-19 Study

• DOI: 10.3390/reprodmed1020007
• Publication Date: 2020-07-23T15:26:01Z
• Authors: Laura L. Jelliffe...; Scott P. Oltman; Larry Rand; Karen A. Scott; Miriam Kuppermann; Rebecca Baer; April Bell; Gretchen Bandoli; Jean Costello; Nadia Diamond-Smith; Elissa Epel; Rebecca Jackson; Fei Jiang; Deborah A. Karasek; Christina Lindan; Allison O’Leary; Jeffrey Olgin; Matt Pantell; Alison Paquette; Nisha Parikh; Noah Peyser; Xianhua Piao; Aric Prather; George Rutherford; Kelli K. Ryckman; Martina Steurer-M...; Jodi Stookey; Ganapati Srinivasa; Hollis Wright; Charles E. McCulloch; Brian Piening; Elizabeth E. Rogers; Christina Chambers
• Keywords: Pandemic

The 2019 novel coronavirus disease (COVID-19) pandemic caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) continues to spread and worsen in many parts of world. As grows, it is especially important understand how virus are affecting pregnant women infants. While early data suggested that being infected with did not increase risk adverse pregnancy or infant outcomes, as more information has emerged, become clear risks for some outcomes increased (e.g., preterm birth, cesarean section, distress, hospitalization). Healthy Outcomes Pregnancy Everyone time disease-19 (HOPE COVID-19) study a multi-year, prospective investigation designed better SARS-CoV-2 COVID-19 impact outcomes. also examines exacerbates existing hardships such social isolation, economic destabilization, job loss, housing instability, and/or family member sickness death among minoritized marginalized communities. Specifically, pandemic-related clinical characterizes experiences Black, Latinx low-income groups compared those other race/ethnicity socioeconomic stratum. includes two nested cohorts. survey only cohort will enroll 7500 over two-year period. survey+testing 2500 this same Participants both cohorts complete short surveys daily using mobile phone application about COVID-19-related symptoms fever cough) longer once during each trimester at 6–8 weeks 6, 12 18 months after delivery focus on health well-being mothers and, have testing related antibodies birth well looks inflammation presence infections like Influenza Rhinovirus. Study results expected be reported rolling basis include quarterly reporting participants public partners traditional scientific reporting.