Sol-Gel Deposition of Iridium Oxide for Biomedical Micro-Devices

• DOI: 10.3390/s150204212
• Publication Date: 2015-02-12T17:08:24Z
• Authors: Cuong Nguyen; Smitha Rao; Xuesong Yang; Souvik Dubey; Jeffrey Mays; Hung Cao; Jung-Chih Chiao
• Keywords: Central Nervous System; Serum; Environmental Science and Management; neurotransmitter sensors; TP1-1185; Biosensing Techniques; Iridium; 01 natural sciences; Article; Analytical Chemistry; Electrochemistry; Animals; Humans; Electrical and Electronic Engineering; Neurotransmitter Agents; Ecology; Chemical technology; sol-gel IrOx; Nernst-response; 0104 chemical sciences; 3. Good health; sol-gel IrO_x; pseudo-reference electrodes; Cattle; dopamine; Distributed Computing; Microelectrodes

Flexible iridium oxide (IrOx)-based micro-electrodes were fabricated on flexible polyimide substrates using a sol-gel deposition process for utilization as integrated pseudo-reference electrodes bio-electrochemical sensing applications. The fabrication method yields reliable miniature on-probe IrOx with long lifetime, high stability and repeatability. Such sensors can be used long-term measurements. Various dimensions of including 1 mm × mm, 500 µm µm, 100 fabricated. Sensor longevity pH dependence investigated by immersing the in hydrochloric acid, fetal bovine serum (FBS), sodium hydroxide solutions 30 days. Less dependent responses, compared to electrochemical processes, measured at 58.8 ± 0.4 mV/pH, 53.8 1.3 mV/pH 48 0.6 respectively. utilized dopamine sensing. baseline responses higher than one an external Ag/AgCl reference electrode. Using same probe working eliminated use cytotoxic electrode without loss sensitivity. This enables employing such recording concentrations neurotransmitters central nervous systems animals humans.