Individual Risk Assessment for Population Living on the Territories Long-Term Polluted by Organochlorine Pesticides

• DOI: 10.3390/toxics11060482
• Publication Date: 2023-05-26T06:00:19Z
• Authors: Aleksandr Garshin; Nazym Altynova; Erika Djangalina; Ozada Khamdiyeva; Gulminyam Baratzh...; Anar Tolebaeva; Zhasulan Zhaniyazov; Elmira Khussainova; Céline Cakir-Kiefer; Stefan Jurjanz; Matthieu Delannoy; Leyla Djansugurova
• Keywords: 2. Zero hunger; Risk; [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health; [SDV]Life Sciences [q-bio]; Chemical technology; [SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy; 610; [SDV.SA.ZOO]Life Sciences [q-bio]/Agricultural sciences/Zootechny; [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain; pesticides; TP1-1185; [SDV.SA.SDS]Life Sciences [q-bio]/Agricultural sciences/Soil study; food habits; 630; Article; 3. Good health; cytogenetic analysis; chromosome aberrations; molecular genetic analysis; exposure survey; 13. Climate action; [SDV.SA.SPA]Life Sciences [q-bio]/Agricultural sciences/Animal production studies; pesticides; chromosome aberrations; exposure survey; food habits; cytogenetic analysis; molecular genetic analysis; [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition

The long-term storage of unutilized pesticides raised new problems of long-term environmental contamination. The study presents the results of surveying 151 individuals in 7 villages living close to pesticide-contaminated localities. All individuals have been surveyed concerning their consumption habits and lifestyle characteristics. An assessment of the general exposure risks of the local population was carried out using the analysis of pollutants in food products and the average levels of their consumption in the region. The cohort risk evaluation revealed that the greatest risk was associated with the regular consumption of cucumbers, pears, bell peppers, meat, and milk. The new model to estimate individual risks of long-term pesticide pollution was proposed as a calculation of the combined action of 9 risk factors, including individual genotypes, age, lifestyle, and personal pesticide consumption rates. The analysis of the predictive ability of this model showed that the final score for individual health risks corresponded to the development of chronic diseases. A high level of chromosomal aberrations was evidenced for individual genetic risk manifestations. The combined influence of all risk factors revealed contributions of 24.7% for health status and 14.2% for genetic status, while other impacts go to all unaccounted factors.