Impact of the Oral Adsorbent AST-120 on Organ-Specific Accumulation of Uremic Toxins: LC-MS/MS and MS Imaging Techniques

• DOI: 10.3390/toxins10010019
• Publication Date: 2017-12-28T16:24:33Z
• Authors: Emiko Sato; Daisuke Saigusa; Eikan Mishima; Taeko Uchida; Daisuke Miura; Tomomi Morikawa-I...; Kiyomi Kisu; Akiyo Sekimoto; Ritsumi Saito; Yuji Oe; Yotaro Matsumoto; Yoshihisa Tomioka; Takefumi Mori; Nobuyuki Takahashi; Hiroshi Sato; Takaaki Abe; Toshimitsu Niwa; Sadayoshi Ito
• Keywords: Uremic Toxins

Elevated circulating uremic toxins are associated with a variety of symptoms and organ dysfunction observed in patients chronic kidney disease (CKD). Indoxyl sulfate (IS) p-cresyl (PCS) representative that exert various harmful effects. We recently showed IS induces metabolic alteration skeletal muscle causes sarcopenia mice. However, whether organ-specific accumulation PCS is tissue still unclear. investigated the using liquid chromatography/tandem mass spectrometry tissues from mice adenine-induced CKD. accumulated all 15 organs analyzed, including kidney, muscle, brain. also visualized immunohistochemistry imaging techniques. The oral adsorbent AST-120 prevented some PCS. In reduced following treatment resulted amelioration renal failure-associated atrophy. conclude can accumulate may be useful treating or preventing CKD, possibly by reducing toxins.