Association of Uremic Toxins and Inflammatory Markers with Physical Performance in Dialysis Patients

• DOI: 10.3390/toxins10100403
• Publication Date: 2018-10-02T12:23:50Z
• Authors: Maja Pajek; Alexander Jerman; Joško Osredkar; Jadranka Buturovi...; Jernej Pajek
• Keywords: Beta-2 microglobulin; Uremia

Association of higher serum levels uremic toxins and inflammatory markers with poorer physical performance is understudied. We measured the six-minute walk test (6MWT), 10 repetition sit-to-stand (STS-10), handgrip strength (HGS), Human Activity Profile (HAP) questionnaire score in 90 prevalent hemodialysis patents, low comorbidity to reduce potential confounding concomitant disease. Midweek pre-dialysis asymmetric dimethyl-arginine (ADMA), β2-microglobulin (B2M), high-sensitivity C-reactive protein (hs-CRP), indoxyl sulfate (IS), insulin-like growth factor 1 (IGF-1), interleukin 6 (IL-6), myostatin, urea were analyzed as predictor parameters measures adjusted models. Serum most not significantly related performance, except for ADMA, which was STS-10 (B = 0.11 ± 0.03 s, p < 0.01). Higher hs-CRP associated results 6MWT −2.6 0.97 m, 0.01) a lower HAP −0.36 0.14, There no other significant associations found. conclude that inflammation may be more important pathway impediment than toxemia. This suggests there large rehabilitation non-inflamed patients.