Ephedra sinica Stapf and Gypsum Attenuates Heat-Induced Hypothalamic Inflammation in Mice

• DOI: 10.3390/toxins12010016
• Publication Date: 2019-12-30T10:49:41Z
• Authors: Wonnam Kim; Wonil Lee; Eugene Huh; Eunjung Choi; Young Pyo Jang; Yun-Kyung Kim; Tae-Hee Lee; Myung Sook Oh
• Keywords: Homeostasis; Proinflammatory cytokine

Ephedra sinica Stapf (EH) exert toxic effects, such as excitability, cardiac arrhythmia, and others. On the contrary, in traditional herbal medicine, EH gypsum (GF) are used most often to treat symptoms caused by external stressors. The hypothalamus plays a crucial role thermal homeostasis. Inflammatory response stressors may affect energy This study investigates effect of GF against heat-induced mouse model. Mice were divided into four groups: saline, saline plus heat, heat treated groups. Heat stress was fixed at 43 °C for 15 min once daily 3 days. Weight ear rectal temperature measurements made after terminating stress. Hypothalamus tissue collected evaluate HSP70, nuclear factor kappa-Β (NF-kB), interleukin (IL)-1β protein expression levels. treatment suppressed increased body temperature. significantly ameliorated weight loss, compared gypsum. Regulatory effects mediated IL-1β reduction. showed significant HSP70 NF-kB inhibition contribute proinflammatory factors promotion hypothalamic