Inhibition of Rabies Virus by 1,2,3,4,6-Penta-O-galloyl-β-d-Glucose Involves mTOR-Dependent Autophagy
PGG; IPS; RABV; antiviral; CVS-11
0301 basic medicine
Rabies
IPS
Virus Replication
Microbiology
Antiviral Agents
Article
Mice
03 medical and health sciences
Autophagy
CVS-11
Animals
0303 health sciences
PGG
TOR Serine-Threonine Kinases
antiviral
Survival Analysis
QR1-502
Hydrolyzable Tannins
3. Good health
Disease Models, Animal
RABV
Rabies virus
Sweetening Agents
Female
DOI:
10.3390/v10040201
Publication Date:
2018-04-18T07:51:13Z
AUTHORS (6)
ABSTRACT
The compound 1,2,3,4,6-penta-O-galloyl-β-d-glucose (PGG), a gallotannin present in various plants such as Rhus chinensis Mill and Paeonia suffruticosa, has a broad spectrum of antiviral effects. The present study investigated its potency against infection of mice with rabies virus (RABV). Results demonstrated that PGG strongly inhibited virus titers (50-fold), viral mRNA expression (up to 90%), and protein synthesis in vitro. Importantly, we found that PGG not only suppressed viral adsorption and entry, but also directly inactivated RABV through suppression of autophagy by mediating activation of the mTOR-dependent autophagy signaling pathway. In vivo, PGG (10 mg/kg) alleviated the clinical symptoms and reduced the mortality of infected mice by 27.3%. Collectively, our results indicate that PGG has potent anti-RABV effect, and merits further investigation as an anti-RABV drug.
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