Inhibition of Rabies Virus by 1,2,3,4,6-Penta-O-galloyl-β-d-Glucose Involves mTOR-Dependent Autophagy

PGG; IPS; RABV; antiviral; CVS-11 Rabies IPS Virus Replication Microbiology Antiviral Agents Article Mice 03 medical and health sciences Autophagy CVS-11 Animals 0303 health sciences PGG TOR Serine-Threonine Kinases antiviral Survival Analysis QR1-502 Hydrolyzable Tannins 3. Good health Disease Models, Animal RABV Rabies virus Sweetening Agents Female
DOI: 10.3390/v10040201 Publication Date: 2018-04-18T07:51:13Z
ABSTRACT
The compound 1,2,3,4,6-penta-O-galloyl-β-d-glucose (PGG), a gallotannin present in various plants such as Rhus chinensis Mill and Paeonia suffruticosa, has broad spectrum of antiviral effects. study investigated its potency against infection mice with rabies virus (RABV). Results demonstrated that PGG strongly inhibited titers (50-fold), viral mRNA expression (up to 90%), protein synthesis vitro. Importantly, we found not only suppressed adsorption entry, but also directly inactivated RABV through suppression autophagy by mediating activation the mTOR-dependent signaling pathway. In vivo, (10 mg/kg) alleviated clinical symptoms reduced mortality infected 27.3%. Collectively, our results indicate potent anti-RABV effect, merits further investigation an drug.
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