Inhibition of Rabies Virus by 1,2,3,4,6-Penta-O-galloyl-β-d-Glucose Involves mTOR-Dependent Autophagy
PGG; IPS; RABV; antiviral; CVS-11
Rabies
IPS
Virus Replication
Microbiology
Antiviral Agents
Article
Mice
03 medical and health sciences
Autophagy
CVS-11
Animals
0303 health sciences
PGG
TOR Serine-Threonine Kinases
antiviral
Survival Analysis
QR1-502
Hydrolyzable Tannins
3. Good health
Disease Models, Animal
RABV
Rabies virus
Sweetening Agents
Female
DOI:
10.3390/v10040201
Publication Date:
2018-04-18T07:51:13Z
AUTHORS (6)
ABSTRACT
The compound 1,2,3,4,6-penta-O-galloyl-β-d-glucose (PGG), a gallotannin present in various plants such as Rhus chinensis Mill and Paeonia suffruticosa, has broad spectrum of antiviral effects. study investigated its potency against infection mice with rabies virus (RABV). Results demonstrated that PGG strongly inhibited titers (50-fold), viral mRNA expression (up to 90%), protein synthesis vitro. Importantly, we found not only suppressed adsorption entry, but also directly inactivated RABV through suppression autophagy by mediating activation the mTOR-dependent signaling pathway. In vivo, (10 mg/kg) alleviated clinical symptoms reduced mortality infected 27.3%. Collectively, our results indicate potent anti-RABV effect, merits further investigation an drug.
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