Printability in Multi-material Projection-Based 3-Dimensional Bioprinting

• DOI: 10.34133/research.0613
• Publication Date: 2025-01-31T13:21:31Z
• Authors: Chao-fan He; Tian-hong Qiao; Xu-chao Ren; Mingjun Xie; Qing Gao; Chao-qi Xie; Peng Wang; Yuan Sun; Huayong Yang; Yong He
• Keywords: 3D bioprinting

Accurately reconstructing the intricate structure of natural organisms is long-standing goal 3-dimensional (3D) bioprinting. Projection-based 3D printing boasts highest resolution-to-manufacturing time ratio among all 3D-printing technologies, rendering it a highly promising technique in this field. However, achieving standardized, high-fidelity, and high-resolution composite structures using bioinks with diverse mechanical properties remains marked challenge. The root challenge lies neglect multi-material printability research. Multi-material far from simple physical assembly different materials; rather, effective control material interfaces crucial factor that governs print quality. current research gap area substantively hinders widespread application rapid development projection-based To bridge critical gap, we developed bioprinter capable simultaneous 6 materials. Building upon this, established fundamental framework for research, encompassing its core logic essential process specifications. Furthermore, clarified several issues, including cross-linking behavior multicomponent bioinks, mismatch interface strength soft-hard structures, penetration viscous within hydrogel polymer networks, liquid entrapment adsorption phenomena porous heterogeneous error source analysis along resolution evaluation printing. This study offers solid theoretical foundation guidance quantitative assessment bioprinting, holding promise to advance field toward higher precision reconstruction more biological structures.