Coexistence of Neurofibromatosis Type 1 and Male Breast Cancer

• DOI: 10.34172/aim.2021.126
• Publication Date: 2021-11-29T06:48:53Z
• Authors: Baris Mantoglu; Burak Kamburoglu; Ismail Zengin; Kayhan Ozdemir; Ebru Kayra; Emre Gonullu; Fatih Altintoprak; Belma Kocer
• Keywords: Male; Neurofibromatosis 1; Receptor, ErbB-2; Breast Neoplasms; Breast Neoplasms, Male; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Receptors, Estrogen; Biomarkers, Tumor; Humans; Female; Receptors, Progesterone

Breast cancer is one of the rarest types of cancer in men. Its incidence increases with age, as in women. Neurofibromatosis type 1 is an autosomal dominant genetic disease that predisposes to many cancer types. Neurofibromatosis and breast cancer have been more frequently distinguished and better studied in women. Characteristically, estrogen, progesterone receptors, negative, and overexpression of human epidermal growth factor receptor 2 (HER2) are detected in patients with female neurofibromatosis breast cancers. In cases reported so far, estrogen and progesterone receptors have been evaluated as positive and HER2 negative in male patients. With the high possibility of breast cancer development in female patients with neurofibromatosis at an earlier age, prompt and careful evaluation is required in terms of both examination and radiological imaging. Unfortunately, there are no thorough recommendations for breast cancer follow-up in male patients with neurofibromatosis. Here, we present a breast cancer, which is an uncommon type of cancer in male neurofibromatosis.