Post-mortem Histopathologic Findings of Vital Organs in Critically Ill Patients with COVID-19

• DOI: 10.34172/aim.2021.23
• Publication Date: 2021-02-20T06:54:43Z
• Authors: Farahnaz Bidari Z...; Shahram Sabeti; Hooman Bahrami-Mo...; Majid Mokhtari; Seyed Sina Naghib...; Parham Torabinavid; Farzad Esmaeili T...; Mahdi Amirdosara; Omidvar Rezaei; Babak Mostafazadeh; Mohammadreza Haji...; Mohammad Mahdi Ra...; Ilad Alavi Darazam
• Keywords: Pathogenesis; Diffuse alveolar damage; Interstitial nephritis

Background : The scientific evidence concerning pathogenesis and immunopathology of the coronavirus disease 2019 (COVID-19) is rapidly evolving in literature. To evaluate different tissues obtained by biopsy autopsy from five patients who expired severe COVID-19 our medical center. Methods This retrospective study reviewed with COVID-19, confirmed reverse transcription-polymerase chain reaction (RT-PCR) imaging, to determine potential correlations between histologic findings patient outcome. Results Diffuse alveolar damage (DAD) micro-thrombosis were most common finding lung (4 5 cases), immunohistochemical (IHC) (3 4 cases) suggested perivascular aggregation diffuse infiltration walls CD4+ CD8+ T lymphocytes. Two cases had mild predominantly lymphocytic infiltration, single cell myocardial necrosis variable interstitial edema samples. Hypertrophic cardiac myocytes, representing hypertensive cardiomyopathy was seen one lymphocytes detected on IHC two cases. In renal samples, acute tubular observed 3 cases, while chronic tubulointerstitial nephritis, crescent formation small vessel fibrin thrombi 1 Sinusoidal dilation, moderate portal inflammation mixed macro- micro-vesicular steatosis all liver Conclusion Our observations suggest that clinical pathology tissue samples could shed more light pathogenesis, consequently management, COVID-19.