Increasing Prevalence and High Survival Rate of Liver Transplanted Patients with NASH and PSC Cirrhosis

• DOI: 10.34172/aim.2024.04
• Publication Date: 2024-03-06T11:57:45Z
• Authors: Zohreh Khajehahmadi; Saman Nikeghbalian; Ghodratollah Rosh...; Sina Mohagheghi
• Keywords: Liver disease; Steatohepatitis; Hepatitis B; Etiology

Background: Epidemiological studies on liver transplant (LT) patients can provide valuable information about the etiology and trends of cirrhosis. The present study aimed to investigate prevalence trend different etiologies survival rates LT at Namazi Transplant Center in Shiraz, Iran, between 2001 2018. Methods: In this single-center, retrospective cohort study, demographic clinical characteristics 3751 who underwent met inclusion criteria, including age, gender, blood group, body mass index, model for end-stage disease (MELD) score, cause cirrhosis, diabetes, were extracted from patients’ physical or electronic medical records Results: MELD scores with primary sclerosing cholangitis (PSC), hepatitis B virus (HBV), non-alcoholic steatohepatitis (NASH) cirrhosis significantly decreased over period (P<0.001). Among patients, HBV infection had highest frequency (21.09%), followed by cryptogenic (17.33%) PSC (17.22%). proportion NASH (both P<0.001) was increased, so that (2016: 19.4%, 2018: 18.8%) surpassed 18.4%, 13.5%), autoimmune 11.7%, 12.7%), 16.1%, 2018:14%) as leading indication 2016 end period. Fortunately, these a better rate than other common diseases (HR: 0.53, CI: 0.43‒0.66; P<0.001). Conclusion: increased during 18 years study. However, an improved rate. Therefore, health organizations should pay more attention non-communicable diseases, especially fatty cholangitis.