A Decrease in the Activity of Inflammatory and Fibrogenic Pathways in Non-alcoholic Fatty Liver Disease as a Potential Defensive Strategy: A Mini-review

• DOI: 10.34172/ajmb.2483
• Publication Date: 2024-03-07T06:28:52Z
• Authors: Sina Mohagheghi
• Keywords: 0301 basic medicine; 03 medical and health sciences; liver cirrhosis; amp-activated protein kinases; fibrosis; Medical technology; non-alcoholic fatty liver disease; transforming growth factor beta1; R855-855.5; hippo signaling pathway

Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of diseases, from steatosis to cirrhosis. Simple remains stable over time, and its development into non-alcoholic steatohepatitis (NASH) takes several years. Several pathways are involved in the progression NAFLD, including transforming growth factor-β (TGF-β), Hedgehog (Hh), Hippo, AMP-activated protein kinase (AMPK) signaling pathways. These have complex interplay, each pathway can either activate or inhibit other This review summarizes evidence implicating that decline activity inflammatory fibrogenic decreases NAFLD. Considering NAFLD their cross-talks, it was expected would increase through occurrence simple steatosis. However, expression decreased The levels Hh ligands, TGF-β1 gene expression, Smad2/3 P-smad2/3 Taz In addition, Fos proto-oncogene, AP-1 transcription factor subunit (FOS), MYC, interleukin-1β, early response 1, AMPK Probably, hepatocyte metabolism is changed decrease risk production different oxidative stress molecules, cellular proliferation, apoptosis, as well responses, potential defensive strategy. should be noted some changes tissue metabolism, reduction, could consequence high-energy balances