Investigation of the effects of Terminalia chebula seed hydroalcoholic extract on Paraoxonase1 enzyme activity in rats

• DOI: 10.34172/jsums.869
• Publication Date: 2024-02-10T12:29:42Z
• Authors: Parastoo Taghipour; Sahar Rostamian; Gholamreza Mobini; Keyhan Ghatreh-Sa...; Mahmoud Rafieian-...; Javad Saffari-Cha...
• Keywords: Terminalia chebula; Medical journal

Background and aims: Paraoxonase 1 (PON1) is related to high-density lipoprotein (HDL) in serum protects against low-density (LDL) oxidation. This study aimed investigate the effects of Terminalia chebula on PON1 hyperlipidemic rats molecular docking some compounds this medical plant activity. Methods: Overall, 40 male (200–250 gr) were randomly divided into four groups, including control group, hyperlipid group receiving 400 mg/kg hydroalcoholic extract T. seeds, 800 seeds. The arylesterase activity gene expression liver tissue underwent investigation. Then, its studied through in-silico studies using AutoDock software (version 4.2.0). Results: decreased (P<0.001) triglycerides from 105.88±10.15 mg/dL 66.88±14.90 74.25±9.51 groups respectively. In addition, aryl esterase increased 202.12±6058 224.34±58.74 (P=0.83) 235.80±37.05 (P=0.6) It also demonstrated a significant effect (P<0.001). results revealed that main antioxidant chebula, such as catechin, kaempferol, quercetin, could bind enzyme directly influence Conclusion: expression. However, among plant’s compounds, quercetin played most substantial role seems these can be useful co-treatments hyperlipidemia therapies.