Identification of Microarn Biomarkers of Prognosis in Type 2 Diabetes Patients Positive for Sars-Cov-2 Variant Delta and Omicron in Nasopharyngeal Secretions in Pointe Noire

• DOI: 10.36348/merjbs.2024.v04i04.004
• Publication Date: 2024-08-07T12:12:19Z
• Authors: Freddy Saturnin P...; Luc Magloire Anic...; Rebecca Frédériqu...; Parode Ragive Takale; Charley Elenga-Bongo; Aladin Atandi Batchy; Christy Parfait N...; Ange Cerna Malong...; Gainze Boyina; Jean Idrice Kélétéla; Cheick Ahmed Dabo...; Saar Abdoul Waha; Siméon Nama; Ghislain Loubano ...; Donatien Moukassa

Introduction: The COVID-19 pandemic has affected the whole world, with a particularly high and severe incidence in patients co-morbidities such as type 2 diabetes (T2DM). Detection of microRNAs human samples may be an alternative to identify effective biomarkers for severity. Methods: We recruited total 206 participants this study. MicroRNA variant analysis were performed on nasopharyngeal using qPCR. study consisted detection 17 microRNAs. Results: majority individuals Delta (68.18%, n=90) had symptoms while Omicron moderate (76.47%, n=13). hsa-miR-29a-5p (AUC 0.80; CI 0.68 0.89 p<0.000), hsa-miR-203a-5p 0.75 0.92 p<0. 000), hsa- hsa-miR-221-3p 0.74; 0.61 0.86 hsa-miR-33b-5p 0.88; 0.98 000) hsa-miR-30d-3p 0.82; 0.70 0.95 p<0.000) have AUCs that indicate good discriminatory ability stratify at risk complications from omicron among T2DM. Conclusion: Our shows hsa-miR-29a-5p, hsa-miR-203a-5p, hsa-miR-221-3p, better discrimination could used prognostic secretions diabetes. They also serve new therapeutic targets.