Klebsiella pneumoniae Infections in Intensive Care Unit and Risk Factors for Carbapenem Resistance

• DOI: 10.36519/kd.2021.05
• Publication Date: 2021-05-06T16:17:20Z
• Authors: Zuhal Yeşilbağ; Yasemin Tekdöş-Şeker; Sevtap Şenoğlu; Gülsüm Oya Hergünsel
• Keywords: Carbapenem; Colistin; Bacteremia

Objective: Klebsiella pneumoniae infections have been a problem in intensive care units (ICU) recent years due to multi-drug resistance. In this study, it was aimed analyze K. ICU, determine distribution of carbapenem resistance rates and risk factors. Methods: Nosocomial (NI) with between January 2017-January 2020 were evaluated retrospectively. cases recurrent infection, only the first episode included. Results: developed total 78 patients. Bloodstream (BSI) most common (51.3%), followed by pneumonia (41%) urinary tract (7.7%). Among BSI cases, 52.5% associated central venous catheter (CVC) 81.2% ventilator-associated (VIP). It observed that while proportion gradually decreasing years, increased. BSI, rate CVC-related increased from 33.3% 2017 62.5% 2019. Carbapenem 52.6% colistin 17.9% isolates both over 3 years. When carbapenem-resistant compared carbapenem-sensitive infections, independent factors found be use (p=0.008, OR: 8.45, 95% CI: 1.76-40.64), prior NI developing different microorganism (p=0.005, 8.70, 1.91-39.65) parenteral nutrition (TPN) (p=0.04, 4.2, 1.06-16.67). Conclusions: Carbapenem-resistant are increasing ICUs, has started recently. Our study showed carbapenems suggested should restricted our unit. is important for each center reveal its own data frequency resistance, order decrease infection control measures antibiotic using policies.