The Effect of Early Administration of Hypertonic Saline Solution İn Acute Decompensated Heart Failure

• DOI: 10.36660/abc.20230818i
• Publication Date: 2024-07-23T20:04:18Z
• Authors: Tugce Colluoglu; Tuğba Kapanşahin; Melahat Hicran Aksu; Orhan Önalan; Yeşim Akin
• Keywords: Clinical endpoint; Hypertonic saline

Abstract Background There was no scientific evidence about the initial treatment of hypertonic saline solution (HSS) in acutely decompensated heart failure (ADHF). Objectives This study assessed impact using HSS along with a loop diuretic (LD) as first for ADHF, focusing on renal function, electrolyte levels, and clinical outcomes. Methods In this retrospective case-control study, 171 adult patients (93 females/78 males) ADHF were included between January 1, 2022, December 31, 2022. Patients allocated into two groups: upfront combo HSS+LD standardized LD. The primary endpoint worsening function (WRF). Hospitalization HF all-cause mortality evaluated during 6 months follow-up. significance level adopted statistical analysis 5%. Results groups exhibited similarities baseline characteristics.A significantly higher diuresis 1st day (3975 [3000-5150] vs. 2583 [2000-3250], p=0.001) natriuresis 2nd hour (116.00 [82.75-126.00] 68.50 [54.00-89.75], found comparison LD.When compared to LD, utilization led an increase serum Na+ (137.00 [131.75-140.00] 140.00 [136.00-142.25], p=0.001 HSS, 139.00 [137.00-141.00] [136.00-140.00], p=.0470 LD), while chloride (99.00 [94.00-103.25] 99.00[96.00-103.00], p=0.295), GFR (48.50 [29.75-72.50 50.00 [35.50-63.50, p=0.616), creatinine (1.20 [0.90-1.70] 1.20 [1.00-1.50], p=0.218) remained stable group when LD (Cl-: 102.00 [99.00-106.00] 98.00 [95.00-103.00], p=0.001, eGFR: 56.00 [41.00-71.00] 55.00 [35.00-71.00], p=0.050, creatinine:1.10 [0.90-1.40] [0.90-1.70], p=0.009). Worsening (16.1% vs 35.5%, p=0.007), length stay hospital (4 days [3-7] 5 [4-7], p=0.004) lower In-hospital mortality, hospitalization HF, similar groups. Conclusion therapy, combined may provide safe effective without impairing ADHF. Therefore, lead shorter these patients.