Modulation of Mitochondrial Function in Elderly Brain: Involvement of Autophagy and Apoptosis

• DOI: 10.36922/itps.v4i2.205
• Publication Date: 2023-01-17T04:46:46Z
• Authors: Pranali Chandurkar; Mrunali Dhokne; Nitu Wankhede; Shubhada Mangrulkar; Brijesh Taksande; Aman Upaganlawar; Milind Umekar; Mayur Kale
• Keywords: Senescence

Mitochondria are crucial cellular organelles that regulate energy production, oxidative balance, and calcium homeostasis, among other things. Aging is a natural, multifactorial, multi-organic process, in which both pathological physiological changes occur gradually over time. Autophagy capacity mitochondrial processes such as mitophagy, biogenesis, dynamics associated with aging. These important for maintaining the structural integrity of mitochondria thus cell life since dysfunction leads to an impairment metabolism increased production reactive oxygen species, may stimulate mechanisms senescence apoptotic death. Furthermore, model organisms humans, decline activity can contribute age-related disease phenotypes. As people age, damage malfunction induce apoptosis, explaining rise Many aging believed be driven by stress. Taken together, evidence strongly suggests relation between function wide spectrum processes. Although there no general consensus studies reviewed, it appears reduces biogenesis dynamics, well mitophagy organism involved. This review describes involvement autophagy apoptosis modulation brain.